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| 1856 |
| | | The treaty of Paris ends the Crimean War, limiting Russia's special powers in relation to Turkey | |
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| 1857 |
| | | David Livingstone urges upon a Cambridge audience the high ideal of taking 'commerce and Christianity' into Africa | |
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| 1857 |
| | | Richard Burton and John Hanning Speke set off from Bagamoyo in their search for the source of the Nile | |
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| 1857 |
| | | The Boers of the southern Transvaal declare independence as the South African Republic | |
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| 1858 |
| | | Burton and Speke reach Lake Tanganyika at Ujiji, a place later famous for the meeting between Livingstone and Stanley | |
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| 1858 |
| | | The end of the Indian Mutiny is followed by brutal British retaliation | |
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| 1858 |
| | | The India Act places India under the direct control of the British government, ending the rule of the East India Company | |
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| 1858 |
| | | The last Mughal emperor, Bahadur Shah II, is deposed by the British and exiled to Rangoon, in Burma | |
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| 1858 |
| | | Speke reaches Lake Victoria and guesses that it is probably the source of the Nile | |
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| 1861 |
| | | Lagos, on the coast of Nigeria, is annexed as a British colony when the royal family prove unable or unwilling to end the slave trade | |
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